The mechanisms of cortical folding in brain development

Project description

An observation commonly made when looking at the human brain is the convoluted, or folded, appearance of the surface. These folds are essential to brain function, as abnormal folding patterns are implicated in a number of neurological disorders. But how do these folds form during development? We will use a novel, multidisciplinary approach to examine the brain during critical periods of fold formation and will determine the underlying cellular mechanisms involved. Our goal is to determine the contribution of axon innervation, cortical growth and the developing vascular system in governing this process. Such knowledge is fundamental for our understanding of brain function and dysfunction.

Project team

Leader: Leigh Johnston

Collaborators: David Walker (RMIT University) Mary Tolcos (RMIT University)

Sponsors: NHMRC

Other projects

Convergence of engineering and IT with the life sciences projects

Research Centre

Neuroengineering Research Laboratory


Biomedical Engineering


Convergence of engineering and IT with the life sciences


biomechanics; magnetic resonance imaging MRI; neuroimaging