Quantitative evaluation of arthritis in the tibio-femoral joint using software and programming tools

Project description

The Integrative Cartilage Research Group at The University of Melbourne researches links between microstructure, mechanics and biological signalling networks. In this project, we are investigating morphometric structural change in animal models due to arthritis.

A large data collection of 3D microstructural images of tibio-femoral joints in mouse and goat models is available for analysis using a custom morphometric imaging software suite.  The data will be pre- and post-processed for analysis and systematically evaluated for a range of metrics that define joint changes due to arthritis disease.

We develop, refine, and use biomedical engineering tools and concepts, to explore and understand the mechanbiology of living musculoskeletal systems on the molecular, cellular, and organ level of organisation, while maintaining a philosophy of respect and compassion for all human and animal life.

The project involves development of software for characterisation of arthritis from 3D image datasets, as well as building computational models for incorporation of structural, mechanical and biological data coming from experiments. Students on this project have a Master degree in biomedical/mechanical engineering, computer science, or a related field with a strong interest in technology and medicine. A good understanding and previous experience in imaging, 3D image analysis or computational modelling is advantageous. 

Project team

Leader: Kathryn Stok

Staff: Zihui Li

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Biomedical Engineering


Convergence of engineering and IT with the life sciences


arthritis; cartilage; medical image analysis