Cardiac cell physiome
This project brings together a multi-disciplinary team of scientists in physiology, computational biology and cellular mechanics to gain a more comprehensive, integrated understanding of how cell-level structure and function affects the whole heart in health and disease. We will develop three-dimensional, biophysically realistic computational models of cardiac cell structure and function in health and disease with two specific aims:
(i) To use the models to understand the effect of sub-cellular structural and biochemical alterations on cardiac cell performance;
(ii) To explore novel treatment strategies using this new virtual cell environment that enables us to appreciate the integrated and multi-faceted response of the cell to a range of clinical therapies.
Students interested in one or a number of the following areas should apply:
- cell mechanics and mechanobiology
- systems biology
- calcium signalling
- image processing and image analysis
- cardiac mechanobiology
- high performance computing
- cardiac hypertrophy, diabetes induced cardiomyopathy.
Students will receive the opportunity to work closely with experimental physiologists, microscopists and engineers to develop a comprehensive picture of how disease related changes in the cardiac cell environment affect its structure and performance.
Leader: Vijayaraghavan Rajagopal
Staff: Edmund Crampin
Collaborators: Lea Delbridge (Physiology), Eric Hanssen (Bio21) , Christian Soeller (University of Exeter)
Systems Biology Laboratory
Biomedical Engineering,Mechanical Engineering
Convergence of engineering and IT with the life sciences
biomechanics; computational biology; diabetes; heart; systems biology