Cardiac cell physiome

Project description

This project brings together a multi-disciplinary team of scientists in physiology, computational biology and cellular mechanics to gain a more comprehensive, integrated understanding of how cell-level structure and function affects the whole heart in health and disease.  We will develop three-dimensional, biophysically realistic computational models of cardiac cell structure and function in health and disease with two specific aims:

(i) To use the models to understand the effect of sub-cellular structural and biochemical alterations on cardiac cell performance;

(ii) To explore novel treatment strategies using this new virtual cell environment that enables us to appreciate the integrated and multi-faceted response of the cell to a range of clinical therapies.

Students interested in one or a number of the following areas should apply:

  • cell mechanics and mechanobiology
  • systems biology
  • calcium signalling
  • bioenergetics
  • image processing and image analysis
  • cardiac mechanobiology
  • high performance computing
  • cardiac hypertrophy, diabetes induced cardiomyopathy.

Students will receive the opportunity to work closely with experimental physiologists, microscopists and engineers to develop a comprehensive picture of how disease related changes in the cardiac cell environment affect its structure and performance. 

Project team

Leader: Vijayaraghavan Rajagopal

Staff: Edmund Crampin

Collaborators: Lea Delbridge (Physiology), Eric Hanssen (Bio21) , Christian Soeller (University of Exeter)

Other projects

Convergence of engineering and IT with the life sciences projects

Research Centre

Systems Biology Laboratory

Disciplines

Biomedical Engineering,Mechanical Engineering

Domains

Convergence of engineering and IT with the life sciences

Keywords

biomechanics; computational biology; diabetes; heart; systems biology